FtsZ inhibitor C109

Research use only, not for human use.

FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.

FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM; inhibits both the GTPase and polymerization activities of purified B. cenocepacia FtsZ, prevents divisome formation by altering the localization of the essential cell division protein FtsZ; displayes antibacterial activity against Gram-positive and Gram-negative cystic fibrosis pathogens, including Mycobacterium abscessus, C109 effectively cleared B. cenocepacia infection in the Caenorhabditis elegans model and exhibited additive interactions with clinically relevant antibiotics.

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Compound 10126109

GPCR/G Protein

Antibacterial

Antibacterial

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285.292

C9H7N3O4S2

>98% (HPLC)

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methyl 2-((4-nitrobenzo[c][1,2,5]thiadiazol-5-yl)thio)acetate

(-20℃)

With Ice Pack

≥ 2 years